The Romero House is located at the northeast corner of the Historic Block. Although it has undergone numerous alterations, part of the building is believed to date from the nineteenth century. It has been maintained not only for its historical significance (its north wall is believed to contain remnants of the original Presidio wall), but also exemplifies the evolution of a home and its occupants.

One of its original residents, Leonardo Romero, was the town carpenter. He became well known for his work on the San Xavier Mission and other important Tucson landmarks. The home continued as a residence for many years but also provided space to various businesses. Physical changes include equipping it with facilities for a restaurant and removing an entire section of the corner for a drive-through gas station. The station later failed and the corner was filled with brick. The house as it stands today is an L-shaped structure. It is impossible to know whether the original was L-shaped or if it was two separate buildings later joined together.

Today, the Romero House is home to the popular ceramics studio Romero House Potters, a non-profit organization offering classes for adults. The Romero House Potters features hand building and wheel rooms as well as both electric and gas kilns.